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There are many available tools with varying levels of accuracy designed to screen for Autism Spectrum Disorder (ASD) in young children, both in the general population and specifically among those referred for developmental concerns. With burgeoning waitlists for comprehensive diagnostic ASD assessments, finding accurate methods and tools for advancing diagnostic triage becomes increasingly important. The current study compares the efficacy of four oft used paper and pencil measures, the Modified Checklist for Autism in Toddlers Revised with Follow‐up, the Social Responsiveness Scale, Second Edition, and the Social Communication Questionnaire, and the Child Behavior Checklist to a novel mobile‐health screening tool developed by Cognoa, Inc. (Cognoa) in a group of children 18–72 months of age. The Cognoa tool may have potential benefits as it integrates a series of parent‐report questions with remote clinical ratings of brief video segments uploaded via parent’s smartphones to calculate level of ASD risk. Participants were referred to one of three tertiary care diagnostic centers for ASD‐related concerns (n = 230) and received a best estimate ASD diagnosis. Analysis and comparison of psychometric properties indicated potential advantages for Cognoa within this clinical sample across age ranges not often covered by another single measure/tool. Autism Res 2018, 11: 1038–1049. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.
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